[Question #6350] Is it possible that taking valtrex can produce a false negative ?

17 months ago
I have had itching, burning sensations, tender lymph nodes, fasiculations, and random body pain but no sores. I have tested both igg and igm for hsv2. I have taken 7 blood tests since my exposure in mid September that all resulted as negative. I am also on valtrex suppression therapy. Is it possible that taking valtrex can produce a false negative of mask my results? 

Also, if you have been infected with hsv2 in one area, is it possible to reinfect yourself with hsv2 ?


Lastly, can herpes cause nerve damage that can cause fasiculations? What can I do to repair nerve damage ?
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
17 months ago
Yes, if you have taken Valtrex daily since your concerning encounter, it could most definitely be interfering with your body's ability to make antibody and thus the test could be a false negative, yes.  Or it could be negative because you are not infected.  Or it could be that the test is just missing your infection.
While it is possible that you could move the virus around in your body during a brand new infection, that is not common and almost always happens only with a new infection, before an immune response has been made.
Herpes does not cause fasiculations (no matter what you read on the internet).  Even if you do have herpes, you do not have nerve damage - that's not how this works - and there is no need to repair anything. 
I would strongly suggest that if you want an accurate antibody test, you stop suppressive therapy and retest in 3 months.  If you get any sort of outbreak during that three month period, have it swab tested for herpes.

Terri
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16 months ago
Are high doses ( 3G’s) of Lysine a great substitute or beneficial for herpes outbreaks and reduce recurrence ? 

Are there other supplements that helps prevent or reduce outbreaks ? 

And how effective is combination valtrex and supplement?
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
16 months ago
There is not good science that says Lysine will be statistically helpful for treating herpes although there are certainly people who believe it is helpful for them.  There is also no research on supplements and Valtrex together.  We have excellent data that Valtrex is VERY helpful in dealing with herpes recurrences and viral shedding.  While a lot has been suggested about supplements, good double blind studies have not been done on supplements.

Terri
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16 months ago

Does a lack of HSV 2 antibodies delay skin repair?


Any knowledge regarding Pritelivir? And is it on fast track with FDA?


Why does the virus decrease outbreak frequency over time? Is it due to hsv2 antibody?


Does HSV 1 antibodies provide some immunity to hsv2 ?

Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
16 months ago
Delay skin repair?  I don't know what you mean here, you mean if you have herpes and for some reason you aren't making antibody, will it delay skin repair of a herpes lesion?
Pritelivir was in clinical trials in the US but the trial was stopped due to some ocular concerns in the mouse model. 
HSV 1 does not protect against HSV 2 but it does make the acquisition of HSV 2 more likely to subclinical.  Outbreak frequency decreases likely as the body's immune system becomes more familiar with how to deal with the virus.

Terri
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