[Question #6667] Following question #6662

13 months ago
Dear Doc, sorry for writing again, I posted yesterday about the window period for a rapid hiv test in Europe (auto test Vih). We have supposed and I was convinced too that it was a 3rd generation test therefore highly reassuring at 8 weeks( I’ve tested negative at 75days) but today I’ve red that almost all the home test in use like Clearview, biosure and autotest vih are 2nd generation test...does it change the fact they can be conclusive after 75 days? Some sites consider them 3rd generation and some other 2nd here my confusion. Thanks in advance for your patience. Regards
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
13 months ago
Sorry to see you back. Correct; Clearview is an IgG-only test (no IgM component) and hence "second generation". Sorry for that error. But don't get hung up on 2nd vs 3rd generation HIV blood tests. There is only a few days difference between them in time to positive results, and that difference is primarily in the proportion that reach conclusive results by 3-4 weeks. After that, their is little difference in their performance. As we discussed before, I am unfamilar with Autotest VIH, but if your research is correct --that it is similar to Clearview -- my statements about time to conclusive results are correct.

FYI, here is the review we use on this forum as our primary resource on time to conclusive HIV test results. It is also the main resource cited by the US Centers for Disease Control and Prevention (CDC).  https://www.ncbi.nlm.nih.gov/pubmed/29140890

HHH, MD
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13 months ago
Thanks again for you clear explanation; I suppose then I can still consider the 75 days negative result conclusive and the 90 days test just an option for peace of mind. 
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
13 months ago
Correct.---
13 months ago
Last question: searching in this forum for topics about 2nd generation tests, in a few questions your colleague states that 2nd generation tests are not in use and sold anymore...but all the tests I mentioned like clearview, biosure uk etc are 2nd generation as you confirmed...I will still consider my 75days result conclusive but I’m only a little confused about the generations 
H. Hunter Handsfield, MD
H. Hunter Handsfield, MD
13 months ago
You're right, more second generation tests are still in use than reflected in past comments. But their use certainly is decreasing and most testing is now done with later tests, especially in the US, where most questions come from and where we operate. in addition, CDC recommends and we agree that the "generation" terminology is outdated ahd shouldn't be used, and we're trying to remember to limit our own use of the terms. In any case, none of this modifies your situation or our advice to you.

That completes the two follow-up exchanges included with each question and so ends your second thread. Please note that repeated questions on the same exposure or topic are discouraged, and excessive questions are at risk for deletion without reply and without reimbursement of the posting fee. Thanks for your understanding. I hope the two discussions have been helpful. Best wishes and stay safe.
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