[Question #6702] Are my test conclusive?

13 months ago
I had a possible exposure 2 years ago. 14 days after I had an negative lab duo and naat. Around 11 weeks after I went back to same clinic and took an rapid Insti test, it was negative. I wanted to confirm so I went to another  clinic and had an Alere Determine combo, it was negative. Now 2 years later I’m still worried so I went to another clinic and they performed an Rapid Stat Pak - negative and they sent blood to the lab, also had another Insti test that was negative2 weeks prior . I assumed that would have been a 4th. Gen test but when I got the results back it was an RNA naat, it was negative also. But I’ve read naats are not reliable if it’s chronic infection. Long story short, are my test conclusive or should I go for a 4th gen. Test?
Edward W. Hook M.D.
Edward W. Hook M.D.
13 months ago

Welcome to the Forum and thanks for your question.  I'll be glad to answer.  You are correct that there have been questions about he reliability of RNA NAATs for diagnosis of HIV but the problem is not missed diagnosis but falsely positive result.  You should consider your RNA NAAT as proof that you do not have HIV.  For that matter, you should also INSTI and other tests performed for HIV and proving that you are not infected.  HIV combination antigen/antibody tests are entirely conclusive at any time more than 42-45 days following exposure. 

You do  not have HIV and you certainly do not need further testing for HIV.  EWH

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13 months ago
Thank you Dr. Hook. But just to confirm, the negative NAAT after 2 years is conclusive? I’ve had 3 Insti test and a Rapid Stat Pak , all after 2 years. But I’m concerned with the accuracy of rapid test. 
Edward W. Hook M.D.
Edward W. Hook M.D.
13 months ago
Repeating your question will not change the answer.  A negative NAAT two years after exposure will prove that you did not get HIV from your exposure of concern.  The results of your Rapid STAT Pak and multiple INSTI tests also confirm that you do not have HIV.  Be confident of this.  EWH
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