[Question #6762] 4th gen accuracy at weeks

12 months ago
I recently dated a girl who said she was tested negative for hiv right before we started a sexual relationship for about a month. After we broke up I had a 4th gen duo test done at 28 days post exposure just for peace it mind. It came back negative. Should I retest at 6 weeks or if you were in my shoes, would just believe the results at 4 weeks?
Edward W. Hook M.D.
Edward W. Hook M.D.
12 months ago

Welcome to the Forum.  I'll be glad to provide some information which I hope will be helpful.  I presume you trust the woman you have mentioned and believe what she said (I would).  The test performance data are the same irrespective and we can say with confidence that more than 99% of infections that were going to occur would be detected at the 4 week period.  The CDC expanded its official recommendation to go out to 6 weeks about two years ago because there are a very small number of instances in which persons became HIV positive on 4th generation tests between 4 and 6 weeks.  The numbers of such cases is so small that there are no studies to describe characteristics of such persons, even two years later.  Neither Dr. Handsfield nor I have seen such a person.  Thus, were I you, I would not bother to re-test at six weeks and would move forward without concern.  Whether or not you re-test at 6 weeks, of course, is a personal decision. 

I hope this information and perspective is helpful.  EWH

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12 months ago
Thank you so much for your prompt reply Dr

Edward W. Hook M.D.
Edward W. Hook M.D.
12 months ago
Glad I could help.  EWH
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