[Question #7078] Follow Up to Question #6841 - HSV2 Reading

8 months ago
Hello - Stemming from the original question I have, currently western blot is in process.  I did have an annual physical with my Dr during this time and she said it wouldn't hurt to perform another HSV2 test with Quest.  The ELISA results came back stating the "HSV IgG screening assay was repeated at Quest and the result was negative; thus the inhibition result could not be determined .  It then states a "reference range of Negative" This is kind of confusing. Does it mean they cannot conclude? HSV2 were 2.72. 
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
8 months ago
It means that the second time they did the test, it was negative, so no confirmatory testing could be done.  The Igg test can be so variable!  Has your blood been sent for the blot yet?  These two results are quite discrepant.  I think you should continue with the blot.  But I think there is an excellent chance that it will be negative.

Terri
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8 months ago
Thanks Terri for such a quick reply (Don’t worry I won’t hold you to it As I know you’re very busy :). Yes bloodwork has been sent to blot, sent it last week.  The discrepancy between the two is kind of shocking. I will continue with Blot and keep you posted. You may leave this open if you’d like otherwise I can give you an update on a new request if you close it. 
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
8 months ago
I will definitely leave this open - I'm very eager to hear.  I think the negative is hopeful but not definitive.

Terri
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8 months ago
Terri- I am happy to report WB came back as negative for HSV2 ! :) thanks for all your help and guidance. It did come back positive for HSV1. That is primarily oral  from my research, 
8 months ago
Sorry accidentally hit submit. That being said WB does have a disclaimer noting that it can’t identify location, but I never had a breakout in the genital area nor in the mouth area actually. Also for future reference if someone has hsv1 and they perform oral on another person, can that person contract hsv1  in the genital region? Thanks again! 
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
8 months ago
It's correct that the western blot cannot tell you the location of the HSV 1 infection.  it can only tell you that you are infected.  If someone has oral HSV 1 and they give oral sex to someone who does not have HSV 1 in any location, yes, they can infect that person with genital HSV 1. Genital HSV 1 is a rather benign infection for most people with few recurrences and little shedding.  If you have any concerning lesions in either the oral or genital area, you should have them swab tested to try to determine the location of your HSV 1 infection.

Terri
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