[Question #7150] HSV in the bladder

8 months ago
I previously asked question 7132. In their replies, Dr. Handsfield and Ms. Warren stated that they thought it unlikely that I have herpes.

However, since asking that question, I tried to stop taking Valtrex but within about a day I started noticing some irritation in my bladder, and by the end of day 2 it had increased greatly, with spasming and a feeling of urgency. I still haven't seen any classic herpes lesions.

This is the second time I have stopped taking Valtrex, believing that I may not have herpes, and the second time that urinary symptoms quickly increased in severity over 2-3 days. I can't imagine it has to do with my anxiety because the symptoms seem too strong for that.

Have you ever seen a case where HSV primarily affects the bladder and nearby tissues, rather than skin? It seems plausible to me that, since it would have infected me close to my urethra, that it settled in the nerves controlling the urinary tract. It just seems like too much of a coincidence that Valtrex keeps these symptoms at bay. Keep in mind this would be an African strain of the virus, which I've read is more virulent. 

Also, I hate to keep bringing up Pritelivir, but could you clarify your earlier answer? When you say that trials were stopped, are you referring to 2016 or to more recent trials?
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
8 months ago
I have not seen a case where HSV impacts the bladder only, no.  I am not aware of any African strain of the virus that is actually more virulent.
The trials in the US were stopped around 2016 although I don't have the exact date.
If you want to be clear about whether you actually have HSV 2, I think you should consider the western blot for the greatest clarity.