[Question #7724] Seroconversion delayed 3 years?

 
24 days ago
I thought I contracted HSV in July 2018 after contact with someone I believe was positive.. I was unable to get a swab test prior to the outbreak (which seemed like a classic outbreak) I got resolving.  I have had 2 other times that I suspected may be outbreaks since then, each about a year apart, but minor and I could get in fast enough for a swab test.  Early on I got a RX for valtrex for suppressive therapy. Initially I took it regularly but eventually scaled way back, but I ramp up taking when I suspect an outbreak or think I may be sexually active. I’ve now taken 6 IGg antibody tests over the years and all have been negative. I asked about this a year ago if it’s possible to have it without antibodies (maybe due to the valtrex). I’m now almost 3 years post contact and just tested negative again.  Would it be possible I still haven’t developed antibodies? I know valtrex can delay but 3 years?  Or am I likely clear?
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
22 days ago
The IgG test misses 8% of HSV 2 infections, compared to the western blot and 30% of infections for HSV 1, compared to the blot.  Are you negative for both HSV 1 and HSV 2?  If you had what you believe to be a classic outbreak with multiple sores, then you need a better test, like the western blot, if you really want to know if you have HSV 1 or HSV 2 or both or neither.  You can work with your own provider to get this test in coordination with the University of Washington or you can work with me at westoverheights.com.  It doesn't matter how you get it but you've been wondering about this for almost three years - it's probably time to sort it out once and for all.

Terri
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22 days ago
Yes, it’s been negative for both HSV1 and HSV2 in all 6 tests. Never even a detectable amount.  I will reach out to you to get the Western Blot.  I agree that at this point I want to know for sure so I can either continue suppressive therapy or move on....Thank you!
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
22 days ago
You're welcome.  Good plan

Terri
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