[Question #7789] Testing Uncertainty

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53 months ago
Hello I had a risk of unprotected oral and frottage which could of resulted in unprotected penetration (I’m not sure if it did or didn’t) with a straight man. I took an RNA test at 12 days post exposure and then a 4th generation test at 28 days. Both came back NR or nonreactive. 

My issue is I took a test at 6 weeks post exposure but my phlebotomist didn’t exactly stick to code. As I’m sure you know it’s common for phlebotomists to call you up then ask an identifying question (DOB or address) to verify they have the correct patient for the correct test. However mine did not that and so I’m concerned my test results may not actually be MY results from MY blood because of this error she made which could’ve led to a patient or test mix up. 

I hate getting my blood drawn so I really would like to not have to go again but I want to ask you guys, are my 2 week RNA test and 4 week 4th generation test considered conclusive if my partner was positive? 

Thank you. 
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H. Hunter Handsfield, MD
53 months ago
Welcome. Thanks for your confidence in our services.

No worries -- for sure you did not catch HIV. The combination of negative RNA at 2 weeks plus negative AgAb (4th generation) testing at 4 weeks is 100% conclusive.

You didn't need the 6 week test. I don't see much risk that somehow the lab mixed up your specimen with someone else's:  the large majority of clinical labs are exceedingly careful about such things. Almost certainly your blood tube was labeled with your unique identifier (probably including a barcode) before the blood was even drawn. But if not, of course I have no better way than you do of knowing exactly what happened. But with the negative results on all your tests, you really needn't be worried about it. You're home free in regard to HIV!

I hope this information is helpful. Let me know if anything isn't clear.

HHH, MD


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53 months ago
Thank you and sorry for my mistake on the last part but the RNA test wasn’t at 2 weeks rather 12 days (close to 2 weeks but not exactly) are my results still conclusive with a 12 day RNA test and 4 week 4th generation test?? 


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H. Hunter Handsfield, MD
52 months ago
12 days is close enough. Your results still are conclusive.---
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52 months ago
Thank you so there’s no need to redo my 6 week test or any further test? I just want to be sure the 12 day RNA and 4 week 4th generation test results are sufficient on their own. Thanks again. 
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H. Hunter Handsfield, MD
52 months ago
Correct, no need. I haven't changed my mind since yesterday!

Here's the mathematic reasoning. Let's assign some estimated odds to the various elements of risk. The chance your partner had HIV 1 in 1,000. The chance of transmission if he di 1 in 1,000. (From those two estimates alone, the chance you caught HIV was around 1 in a million.) The chance your 12 day RNA test missed an HIV infection is around 10%. The chance your 4 week AgAb test also missed it is around 1%. So the chance you have HIV calculate as 0.001 x 0.001 x 0.1 x 0.01 = 0.00000001, or one in 100 million. If that isn't zerorisk, I don't know what is! (Putting it in perspective, if you live in the US, the National Safety Council esimates there's 1 chance in 1,756 of any particular American dying of an accident (vehicular, fall, drowning, fire, etc, etc) per year. In other words, the odds youll be gone in the next 12 months from an accident are 57,000 times higher than the possibility you have HIV!

So I guess my final advice is to stop worrying about HIV -- but don't forget your seat belt and check those fire alarm batteries!
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52 months ago
Of course. I just wanted to be sure that it still applied with the 12 day RNA test instead of 2 weeks. Thank you tremendously. 
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52 months ago
And also considering I’m not counting the 6 week test because I don’t trust it was done properly. 
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H. Hunter Handsfield, MD
52 months ago
I don't think there is any possibility it was not done correctly. These tests are highly automated and I've never heard of a procedural screw-up that altered the results or their reliability. And we already discussed the low chance of confusion with another patient's specimens. Neither of these is a realistic concern. In any case, you didn't need that result to know you don't have HIV.

That completes the two follow-up exchanges included with each thread and so ends this thread. I hope the discussion has been helpful. Best wishes and stay safe.
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