[Question #7791] Hello
52 months ago
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Hi Experts, I think it’s wonderful what you are doing here. I have three questions regarding HIV
I understand the risks, what constitutes testing and what does not. I have so far tested negative with fourth generation on day 20 and 24. So my questions are as follows:
1. If I wanted to get conclusive results the quickest way possible, should I get a 4th generation and RNA test done on day 28 or will I need to wait until day 42 to take a 4th generation?
2. Is my day 24 test a good indication that I do not need to excessively worry about day 28 results?
3. The Scripps HIV vaccine that is showing great success during the first round of human clinical trials, is that preventative or therapeutic? Do you believe there is a cure on the horizon?
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Edward W. Hook M.D.
52 months ago
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Welcome to our Forum and thanks for your questions.
1. How soon a person can consider their results conclusive is challenging. In general, currently available, 4th generation combination HIV antigen/antibody tests are considered absolutely conclusive at 6 weeks (42 days) after exposure. At 4 weeks (28 days) 4th generation tests are more than 99% conclusive. RNA PCR tests generally become positive sooner than than the 4th generation tests. The advertisers say that their results are conclusive at 11-13 days after exposure but most experts would like to see negative RNA PCR test results confirmed with a 4th generation test 4-6 weeks following exposure. In general, if a HIV PCR RNA test is negative at 11-13 days and a 4th generation test is negative at 4 weeks, I would consider those results absolutely conclusive.
2. I would consider it very strong evidence that your subsequent tests will be negative.
3. The Scripts vaccine is targeted to be a preventative vaccine. The current trial was a phase 1 trial which does not provide data regarding it's efficacy and is considered a "proof of concept" trial. There is much to be done before you can bank on it's success. OTOH, it uses new technology which is hopeful and promising
Hope this information is helpful. EWH
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52 months ago
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Hi Dr. Hook, thank you for the response. I received a negative duo test at 30 days, though, my mind isn’t quite letting me breathe a sigh of relief. I’m sad the window moved from 4 weeks to 6 weeks. The days are so long. Is it only immunosuppressed and those who have taken pep who would test positive after 4 weeks?
Also, if I had sex on day 7 after potential exposure and tested negative duo on day 30, can I be sure, even if I tested positive at 6 weeks, that I would not have infected this person on day 7?
Thank you,
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Edward W. Hook M.D.
52 months ago
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There are so few cases of persons whose tests become positive between days 28 and 42 that it is difficult to determine what characteristics are associated with late seroconversion. As I've said, well over 99% of tests which will turn positive do so by day 28. I really would not worry that the partner you exposed on day 7 following your exposure of concern will be infected. I think you are worrying much more than you need to. EWH---