[Question #7967] I am devastated part 2

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50 months ago
So after the 8 weeks 4th generation HIV test, which was negative I did not took anymore test because testing for me was terrible stressful. I tried to convince myself that I am ok and no more tests are needed.

So I was still completely devastated abot the HPV thing, so I studied it on internet and find out that AHCC supplement was studied for eradication of HPV with nice results. I took it, even if my last PAP was A, so at least for that point I was happy because I read in many sources that HPV was just a transient infection for most people and most of the sources said the immune system can eradicate it.

Than on your forum I read that your opinion is that -hpv stays in the body forever, it completely devastated me. I feel like I made the most horrible mistake in my life and I will pay for it forever. I also developed 2-3 very small bumps on my gingiva, a couple of month ago, and now I am scared that this is gingival papilloma and I feel horribly terrified. This thing is hunting me and putting me in stress for more than 2 years now.

Are you really sure HPV stays with a person forever?

Can I be sure I dont have HIV if the 4th generation test 8 weeks after the sex was negative?

Am I at risk for oral or troat cancer?

Can I trasmit the HPV in the household?

Its 2.5 years now that I am single and I did not have sex in all that time. I feel terrible. I am 33 years old. 
I got the HPV vaccine after I found out about the diagnosis. My last PAP was A.

Thank you for your time and words.

Larisa
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Edward W. Hook M.D.
50 months ago
Continuing my responses, please note that because these questions are somewhat different from those in your initial question I have chosen to go on and answer them. Having said that however, we allow clients to add second and third questions during their up to two follow-up opportunities associated with each question without additional charges. I have chosen to answer this question separately in order to provide you with a timely answer but want to Encourage you not to use multiple postings.

Thanks for reading some of our previous posts on the topic of HPV infections. This is a complex topic for which new knowledge is being developed all the time. The vast majority of HPV infections detected during Pap smears become no longer detectable during follow up Pap smear testing over a period of 1 to 2 years. Thus the recommended approach to follow up as your gynecologist Has suggested.  The vast majority of HPV infections detected during Pap smears resolve and are no longer detectable with the passage of time, most typically 1 to 2 years. Recommended follow up is to repeat the Pap smear studies to make sure that there is no progression of Pap smear abnormalities which can rarely occur and may warrant further tests or therapy for a minority of infected persons.

More recently however, highly sensitive research tools have shown that while evidence of HPV infection in Pap smears resolves over time, small amounts of HPV DNA can still be detected in tissue using these highly sensitive research tools. This information is important because it does indicate a small possibility of recurrence over time and validates recommendations for continued periodic testing as recommended over the life course to detect the relatively infrequent recurrences which do occur.  

I would not worry about throat cancer. While persons performing oral sex on HPV infected persons do occasionally acquire HPV and rarely these infections progress to cause cancer of the throat and oropharynx, dentists check for evidence of such infections during the regular check ups. There is no specific testing recommended for detection of HPV in the throat. I would not worry about it other than them to continue your regular dental care.

Please don’t worry about household transmission of HPV. It is not a meaningful consideration.

Congratulations on having gotten the HPV vaccine. This will prevent future new infections and recent data suggests that it may also Reduce risk for recurrence in persons with existing infections. 

I hope the information I have provided is helpful to you. I am sorry for the challenges your recent relationship post and hope that the information I have provided will be helpful to you going forward. If there are additional questions or anything I have said is unclear, please do not open a new question but use your up to two follow-ups for clarification. EWH
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50 months ago
Dear Dr Hook,

Thank you so much for your words.

My dentist saw the very smal lumps that I have on my mandibular gingiva, and he thought it is a gingivitis caused by plaque formation. He did not mention anything about papillomas, so I did not mention that I was afraid about that specific diagnosis, beause I do feel ashamed.

1) Do you think that if it would be gingival papilloma a dentist would recognise it as such?
Do you think after 2.5 years and after vaccination it would be common that a papilloma arise on my gingiva ( there are 3 small lumps that are symetrically situated under the interdental papilla on the alveolar ridges, just 3 very small lumps, not a cluster like the pictures on google).

2) Can Iive a normal life in the household ( I am still living with my parents and my sister and brother)?
At the beginning after the diagnosis I was washing my underwear separatedly and disinfecting the toilet after every use and I was still concerned that I would trasmit something through the forks and plates when eating.
Is it enough if the forks, spoons and plated are just normally washed and I do not share them with others ( in case I would have oral HPV).
I was living a nightmear thinking that I could pass it to somebody in the household and it would mean a world to me to come back to normal life that I had before the HPV.

3) Is the fact that my PAP smear normalized in 1 year a sign that my body has produced enough antibodies that cleared the infection or can I expect some more trouble from the HPV? 

4) In Texas a group is doing a Clinical Trial with AHCC suplement and the doctor that is doing it wrote that they believe the virus was copletely cleared from the body. The reserch is also on PubMed. Do you think nobody completely clears HPV? It would be much more easy to live with this idea than with the idea that is permanent.

Thank you from the heart.

Larisa 

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50 months ago
In Covid PCR testing the researches found out that the PCR test were still positive some time after the resolution of the disease, due to virus DNA fragments, but that did not represent a possibility that the virus would linger there forever, because it was just DNA fragments. They were detected due to an extremely sensitive method that PCR is.
Do you think that it would not be possible that also the HPV fragments that remain are just fragments without a clinical importance?
PCR is a very sensitive test, so if somebody has a PCR HPV test negative wouldn`t it be enough to think that there is no clinically important virus present anymore?
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Edward W. Hook M.D.
50 months ago
1.  If the papilloma noticed by the dentist were a wart, he would have arranged for further testing.  There are many normal papilla througho8ut the inside of the mouth.
.2.  You can live a normal life.  you can wash your cloths with others, do not need to worry about sharing eating utensils or glasses.  HPV is not transmitted through these sorts of contacts.
3.  Yes, the fact that your Pap smear became normalized within a year is a good sign and indicates no meaningful risk of transmitting it to others or having complications.  As I mentioned above, just continue to have your recommended sexual health checks at recommended intervals. 
4.  Questions about complete clearance are difficult questions to answer however HPV DNA is only detectable in a portion of persons who have achieved clearance, suggesting that in some, perhaps most, persons complete clearance can occur (it is difficult to provide more precise figures on this).

Hope this helps.  EWH
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50 months ago
Dear Dr Hook,

So if I undesrtand you correctly there are some people in whom teh virus gets completely erased from the body like the flu? 

Thank you so much.
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Edward W. Hook M.D.
50 months ago
Yes, that appears to be the case.  Before you ask and since this will be my final reply as part of this thread, please appreciate that., following clearance of the sort you have experienced,  testing to try to determine whether there is residual HPV DNA not detected by standard methods is not something that should be done outside of a research setting and that to do so would be a waste of time and resources.

As mentioned above, this completes this thread.  I hope my comments have been helpful.  Please note that repetitive, anxiety-driven questions may be closed without a response and without return of your posting fee.  Take care.  Please don't worry.  EWH
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