[Question #8015] The case of Mississippi Baby (for Dr., Handsfield)
49 months ago
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Dear Dr. Handsfield,
Sorry, I am here to ask questions again. Please don't be mad. Please kindly help.
I had two exposures in the same week, only four days away. I was on Triumeq PEP(not Truvada PrEP) at 40 hours after the second exposure, but I didn't complete the full 28-day course. I took 7 Triumeq in six days (I took it twice on the third day to adjust medication timing, so it’s a 6-day-7-pill course, not 6-day-6-pill nor 7-day-7-pill.)
I feel relived after reading your replies months ago, but recently I started feeling worried after knowing there was a case of "the Mississippi Baby" the other day. (https://www.hiv.gov/blog/mississippi-baby-now-has-detectable-hiv-researchers-find)
The baby was reported to become HIV
positive after a 27 month of HIV negative responses. She received
antiretroviral therapy at 30 hours after her birth and the therapy continued 18
months.
Dear Dr.,
It seems early antiretroviral therapy can
lead to long term HIV negative responses after it was stopped. I am wondering if I was infected in the first
place, whether the virus can hide somewhere in my body (in latent reservoirs)
for years and just hasn't been activated yet due to the 6-day-7-pill Triumeq
course, just like the Mississippi Baby and other adults HIV patients who
received very early antiretroviral therapy and experienced years of HIV
negative responses after the therapy stopped, but the virus was activated and
rebounded after years. (https://pubmed.ncbi.nlm.nih.gov/20549847/)
I am afraid of the possibility that I am just like them and that the tests results I have had are false negative because of the 6-day-7-pill Triumeq PEP (as a form of antiretrovirl therapy). The HIV combo ag/ab test came back negative at 42 months after the 6-day-7-pill Triumeq PEP course and RT PCT test is Target Not Detected at 24 months. I haven't had any exposure since then.
Dear
Dr., Handsfield, Are my doubts warranted? Please don't be mad, thank you very much!
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H. Hunter Handsfield, MD
49 months ago
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