[Question #8305] Herpes Supplemental Test Results?
46 months ago
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My husband and I are trying to properly understand and interpret his HSV2 test results. It appears that it's negative, but we are unsure. My husband had a possible very slight exposure on 8/16/21 and has no symptoms. The APRN said that she had never seen this Supp test before and it was clear that she didn't know how to properly interpret it. The test was done on 9/24/21 (LabCorp). We want to know if this is negative or if he needs another test. I don't feel comfortable with any exposure to me until we know if this is negative? For HSV 1, my understanding is that about 70% of Americans have this (cold sores that often appear on lips). We've been together for 27 years, and my husband probably had a cold sore years ago. I'm sure I had one once or twice years ago as well. So not so concerned about that. It has never caused me any problems. Thank you. HSV2 IGG, 1.69 Index, 0.00-0.90 index HSV2-IGG SUP TEST, Negative, Negative HSV 1, 18.90 index |
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Terri Warren, RN, Nurse Practitioner
46 months ago
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So your husband had what we call a low positive HSV 2 result. Low positive is defined as 1.1 to 3.5. The supplemental test is a point of care test called Biokit. There is quite good correlation between a negative supplemental Biokit and a negative herpes western blot (the gold standard antibody test from the University of Washington). On the other hand, there is poor correlation between a positive supplemental test and herpes western blot. So good that his was negative. Between a "very slight exposure" (and I have no idea what that means), no symptoms, a low positive and a negative supplemental LabCorp test, I think there is an excellent chance that he is truly uninfected.
Terri
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46 months ago
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Hi Terri,
Thank you so much for your reply! I have been waiting to hear from you.
To answer your question - low exposure in this case was the fact that my husband was with a woman who was touching him with her hand (hand job - unseemly woman who seems to make a habit of this type of behavior). He was lying on a table and she was standing over him at the foot of the table. He explained that he felt her lips touch him and he jerked over to the side and hopped up and said No. Nevertheless, given that her lips touched him however slightly for however short a period of time, we wanted him to be tested for everything. This happened approximately 8/16/21 and all the tests were done on 9/24 except for 2 (gonorreah and some other little protoza thing I've never heard of) which were done on 9/23/21. They were all negative. The only thing with any sort of positive was the low pos. HSV2 test followed by a Negative Supp HSV2 test. It just makes me wonder why it was positive at all (even very low) and then Negative. Though I can say that my husband had shingles 2-3 years ago, and I remember hearing or reading something about that maybe causing incorrect HSV2 results.
Aside from that, I have just one follow up question please. I want to make sure the time between the incident on 8/16 and the tests on 9/23-24 was enough to get accurate results. We have been together for 27 years!! So you might imagine this was pretty upsetting. However, I am unwilling to risk my health, and want to make sure I have as accurate of results as I can get, and even with that, it will probably be condoms for an extremely long time going forward,. I am most concerned that there was enough time on the HIV test (done 9/24). He did the HIV AG/AB test. The results were NON-REACTIVE, "Non-Reactive: HIV-1 antigen and HIV-1/HIV-2 antibodies were not detected.There is no laboratory evidence of HIV infection."
My bottom line follow up question is is it enough time between 8/16 and the tests done on 9/24 or 9/23 to expect accurate results (especially for the HIV test). Thank you so much for your time and help!
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Terri Warren, RN, Nurse Practitioner
46 months ago
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The HIV result timing is fine. You can count on the negative HIV test result. Not to mention the fact that the behavior involved is not a risk for HIV.
The herpes testing time is a bit short. However, the type of contact he had is not a risk for HSV 2, neither the hand job nor a very brief touch of her lips. The risk for oral sex (and I wouldn't even describe the contact as oral sex) is HSV 1 which he already has, so that isn't an issue either.
If you want greater reassurance, he could test again when 12 weeks have passed since the encounter, but honestly, from what you've described here, if it is all accurate, I wouldn't give this a second thought in terms of risk.
Terri
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