[Question #8806] Testing

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39 months ago
I was originally diagnosed with HSV type 1 in 2009 they did a culture as well as blood test. I also had a follow up culture and another blood test that confirmed HSV type 1. I went to the gynecologist in June and April for two vaginal lumps that they did a culture on and came back negative for either type 1 or 2.  I went again about two weeks ago for a vaginal lump and the doctor reported that she believes I am experiencing ingrown hairs that have become infected. She recommended that I do blood work again and wrote an order for HSV IGM and IGG.  Unfortunately, the lab messed up and only ran HSV IGM which was negative for both. I experience extreme anxiety waiting for the results. My question is do I repeat the IGG test? Also, QUest diagnostic has the Herpes select IGG type specific antibody testing ELISA and I was informed I can receive the results in 1 day.  Im not sure if it is worth putting myself through this test. I was considering just doing the HSV 2 test.  Im concerned about possible false positive.  
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Terri Warren, RN, Nurse Practitioner
39 months ago
The IgM test is poor and should not be relied upon either way - positive or negative. 
If there are hairs coming out of the bumps, then they are likely to be ingrown hairs and not herpes. 
I am assuming that your HSV 1 was genital, yes?  You mentioned that the swab and culture were positive for HSV 1 but didn't mention from what locationl.
We can look at your values if you do test, if positive and help you know if you should obtain a confirmatory test, if you do it.
What are thinking at this point?

Terri
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39 months ago
Yes I was diagnosed with HSV 1 genitally in 2009.  I tested again with blood draw in 2011 which was positive for HSV i (17.0 was the values) and the negative for HSV 2 (0.02 was the value).  After a six month relationship in which I only engaged in oral sex once with my partner I decided to do the lab work again which was in 2019 and I had waited well over 3 months to test. my value was positive again for HSV 1 and negative for HSV 2 however the value went up to 0.10.  Should I be concerned that my values for HSV 2 fluctuated, however, remained in the negative value range? That is the only reason I was considering going through with the lab work again this time because my values for HSV 2 fluctuated from 0.02 to 0.10 from 2011-2019. 
I’m just concerned about retesting with blood test and getting a false positive.  Is it better to test at a regular lab or is it okay to test with the rapid at Quest diagnostics?
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Terri Warren, RN, Nurse Practitioner
39 months ago
No, you absolutely should not be concerned that the negative value fluctuated.  I would be more concerned if it didn't!  It is very normal to fluctuate.  
I'm not sure about the distinction that you are making between a regular lab and a rapid test at Quest - Quest is a regular lab.
But I don't think you need another test.

Terri
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39 months ago
Thank you so much for all of your help! This settles my mind because I was so concerned about the fluctuating values for HSV 2. This is a wonderful service you have for people
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Terri Warren, RN, Nurse Practitioner
39 months ago
Happy to be of help!

Terri
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