I was diagnosed with genital herpes when I had a bad yeast infection. I’ve taken valtrex regularly (either daily for a period or as needed) for the last decade. I recently asked for a blood test and my igG came back negative (<0.91). Is it possible to have HSV-2 if igG is negative and should I get tested again?

Some additional information, I was able to get my past test from a decade ago. The doctor ordered a Cytomegalovirus (CMV) and HSV 1&2 igM.

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My original test was from bloodwork. They did not do a swab from the records they provided me. I’m not sure why my old dr ran the CMV test. I don’t have HIV or a compromised immune system. 

You've never had a reliable test to say that you have herpes.  The CDC says never to do use it to try to diagnose HSV.  And your current test is negative.  The IgG test misses 30% of HSV 1 infections and 8% of HSV 2 infections, compared to the gold standard western blot.  The Valtrex question:  Have you had at least three months off of Valtrex in the past decade?  If yes, then your body has had an opportunity to make antibody off drug.---

Hi Terri - I really appreciate your advice and insights. After my results, my PCP and I discussed discontinuing valtrex and retesting in 3 months. 

I think it is fine to discontinue your Valtrex, absolutely. Remember if you are truly infected, that would make any sex partners more vulnerable to becoming infected. But have you been off Valtrex for a 3 month period prior to this in the past 10 years?  If yes, then the testing should be accurate now.  But your call.  If you need further help, come back and post again.  I'm guessing your visual diagnosis may have been incorrect.  Or if you were diagnosed by IgM test alone, that was a very significant error.  Best to you!---
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