[Question #8847] Continuing worrying symptoms
39 months ago
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Hello Dr. Handsfield/Dr.Hook
Unfortunately I am here again regarding my persisting health issues that started approx. 1 year ago after a high risk exposure.
In the last question i discussed with Dr. Hook about possible autoimmune triggers of my symptoms. Investigation shows that markers for autoimmune diseases are all negative.
Furthermore, I'm experiencing alot of dermatological issues ever since. I have been diagnosed with Chronic pustular folliculitis (biopsy was not yet done, but Dr. Thinks its eosinophillis folliculitis because of multiple failed treatments: Doxycycline for 3 months, Amoxiciline, Isotretinoin, Roaccutane, topical strong steroids, benzoyl peroxide, hydrogen peroxide, antihistamines, vitamin D, mechanical cleaning of the skin, seitching showering gel for Syndet and so on....
The pustules are leaving dark hyperpigmentation afterwards and are popping up all over body. Recently, i developed seborrheic dermatitis of the face (dr. Says it is not related to Roaccutane use). Another dermatologic issue is melanonychia. It started as only 1 vertical brownish stripe on thumb, now (few months later) it has spread to other fingers.
Alongside mentioned dermatologic issues i still have tender cervical and ocassionaly axillar lymphadenopaty. MD said that those are most likely reactive and are not that big. The tenderness switches from node to node, and when one is affected it becomes hard but withing hours it switches off and moves to another node or subsides for some time. The most affected are occipital nodes, and the ones behind angulus mandibulae. Internal fatigue is ocassionaly present.
Now, my Dr. Derm. Med. Suggested repeating HIV test. My last test was a rapid insti test (which was done as part of my routing yearly checkup) and it was 11 months after the risky exposure i described in recent posts. Is there any need for that? I did not have any high risk nor low risk events ever since. I completely stopped my sexual activities (which were not frequent anyway)
39 months ago
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I forgot to mention the tests i did:
HIV - a bunch of them as described before. Last 4th gen was at 9 months. Quantitative PCR at around 6 months, and INSTI HIV/Syphillis at 11 months
HBV - vaccinated + HBsAg at 9 months
HCV - negative at 4, 9 months
Syphillis - negative at 2,3,6 months with ELISA or TPHA, and at 11 months with INSTI. (I guess the doxycycline duration would eliminate it if it were present; 2x 100 mg for 2 weeks, 1x 100mg for 6 weeks, 2x 100 mg for a bit less than 2 weeks.)
Gonorrhea - Urine and saliva Architect DNA PCR - negative at 7 months
Chlamydia - Urine and saliva Architect DNA PCR - negative at 7 months
(Again, i believe the doxycycline would clear it)
ANA - negative
EBV - had it in 2005. IgG positive
CMV - igG positive
Toxoplasmosis - negative
ASTAL - negative
AST/ASO - negative
Celiac tTg-IgA - negative
Covid-19 - negative + double vaxxed with Moderna.
CBC shows persistent borderline elevated lymphocites (3,6-4,1) and elevated eosinophils (around 0,7-0,8), elevated serum iron (40, reference range is up to 32). Liver enzymes are normal, as well as all Immunoglobulins (igG,igM,igA,igE). Cr-P and ESR are low- normal - 0,4 & 2 respectively.
Peripheral blood smear differential shows lymphocites at 0,53, segmented neutrophils at 0,39, eosinophils at 0,07 and monocytes at 0,01.
I forgot to mentioned chronic loose stools/diarrhea as a symptom. Leukoplakia on tongue was also present for few months but it is not anymore. (It looked like white hairs)
So i thought that i finally got rid of HIV scare, but now i have doctors advice to retest. That would be around 13-14 months now. :(
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H. Hunter Handsfield, MD
39 months ago
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Welcome back, but I'm afraid we can't help much at this point. You are re-asking all the questions covered in detail in your previous three threads, which I scanned before replying this time. I'll start with my opening reply to your very first question nearly a year ago:
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"One of the most consistent and frequent themes on this forum, and the basis for much of our advice, is that the current HIV blood tests collectively are among the most accurate diagnostic tests ever developed, for any medical condition. ...when done sufficiently long after the last positive exposure, the results overrule all other considerations: no matter what symptoms are present or the level of HIV risk at the time of exposure, the test result rules. For the antigen-antibody tests you had (AgAb, "duo", 'combi"), that interval is 6 weeks.... Accordingly, your results are to be believed: all tests at 6 weeks and more (and for practical purposes, the one at 4 weeks) were conclusive."
There were similar replies and comments in your next two threads as well, both about HIV and all the other tests you had for all known sexually transmitted infections, including several that are so rare that they should have been ignored anyway. As for your symptoms, we do not have advice about the cause of symptoms other than HIV and other STIs. Once those problems are excluded -- as they have been by all the tests you report -- we don't try to judge other causes. It seems Dr. Hook might have had some comments about potential autoimmune explanations, but that was an exception to our usual approach.
As for your doctor's advice to have another HIV test, I have to suspect that your own (repeated?) concerns about HIV have led him or her to retest you for reassurance. Some physicians also may suspect some patients to be at risk that they deny or don't recognize. So I don't fault your doctor for retesting you, but I remain confident the results again will be negative. I also remain confident that whatever the cause of your various symptoms, they are not due to any infection of any kind from the sexual exposure you are concerned about. The only potential relation to that event is psychological -- i.e. the possibility that many of them reflect increased awareness of minor symptoms or even normal body sensations that otherwise would not concern you or perhaps would not even be noticed.
I'm sorry I can't be more helpful. If you remain concerned (as I expect you will), I suggest you go back and re-read your other three threads in detail. In any case, this must be your last question about this exposure, your symptoms, and your STI/HIV concerns. Repeated questions on the same topic are not only discouraged, but eventually are deleted without reply and without refund of the posting fee. ASHA does not want to collect fees for questions with obvious answers; repeated response tend to prolong anxiety and worry rather than resolving it (there's always a "yes but" or "am I the exception" sort of question, to which the answer always is no); and repeated questions have limited value for education of other readers, one of the forum's many goals. Thank you for your understanding and best wishes.
HHH, MD
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39 months ago
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Thank You for your reply Dr.
I understand that I'm repetitive. Im just lost at this point. I tried talking to two shrinks, but they both told me that my problem is obviously physical of nature and that they cannot help nor treat it. All dermatovenerologist's treatments failed. I'm planning to visit haematologist next.
Could you leave this subject open? I will go for another test that will be 13-14 months after a single event, and post the results here.
And when i find out eventually what this thing is, can I post the final diagnosis for others to see?
Thank You!
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H. Hunter Handsfield, MD
39 months ago
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There will be no point in posting your upcoming negative test result. However, threads are kept open for four weeks or two follow-up comments and replies, whichever comes first. So you have one more coming; feel free to use it to post your additional HIV test result. However, if or when a single unifying diagnosis is found, I don't see that it would be of particular value to other forum users; probably nobody comes to this forum in hope of getting clues to their own problems other than HIV or other STIs, and I do not expect to leave the forum open for this reason.
My reply above may have over emphasized psychological origins of your symptoms. Some the issues you describe clearly are physiological, not psychological. But that doesn't imply they are sexually acquired or due to infection. Almost certainly the pustular dermatitis you describe is not infectious but immunologic, as your dermatologist apparently would agree. There are plenty of persons in this world who have unexplained inflammatory medical conditions, and someday perhaps you will be diagnosed with a particular disorder. But not necessarily; some persons never have clear explanations. In any case, given the nature of these problems and the tests you have had, I presume and hope your doctor(s) include an infectious diseases specialist. If not, such consultation would make sense.
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38 months ago
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Good day Dr. Handsfield!
I am just informing You that i went for HIV (ELFA, BioMerieux) 4th gen and Syphillis (ECLIA by Roche IgG/IgM) tests.
Both are, as expected - negative.
That marks > 13 months post exposure testing. I am now putting a stop on those tests now, and will look elsewhere for the cause of my problems.
Thank You very much for Your help!
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H. Hunter Handsfield, MD
38 months ago
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Thanks for the thanks, and I'm glad (but of course not surprised) your latest test was negative. I hope it's your last. Please heed the forum policy discussed above. Thanks. ---