[Question #9020] Very High Risk HIV Exposure

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37 months ago
Hello Doctors
I was recently exposed to HIV with a CSW in Zimbabwe. I was having protected sex then suddenly the condom broke. I was a bit drunk but I remember withdrawing almost immediately (1 - 5 seconds max). I stopped and changed the condom which then broke again and I pulled out instantly. I changed and finished the act protected with a new condom. There might have been some defects with the condoms. I was very worried that I was exposed and I asked the Csw about her status and she said she was okay but I wasn't convinced and I bought self test kits and brought them the next day. At first she refused to test but then agreed later she didn't want to know the results so I tested her and went away with the kit to my horror I found out she is positive (double line on the kit)  and probably she is not on treatment as she lied at first about her status.  I was terrified and quickly went to an emergency clinic and I was given an injection for bacterial STIs and I was prescribed PEP after 30 hours of exposure ( Lamuvudine, Tenefevior and Dolutegravir).
Exactly 7 days after exposure I developed a cold sore on my lips I do have HSV1 and I get outbreaks here n then but I was freaked out, is it a coincidence or maybe its ARS or the PEP is failing?

With your very Expert opinions:
1.What are my chances of contracting HIV since she is positive and not on treatment?

2.Is my PEP treatment after 30 hours going to prevent transmission?

3.I have a wife,  and I have been avoiding sleeping with her, will I put her at risk if I engage in unprotected sex with her?

4.I'm taking PEP consistently everyday sametime in the morning can you let me know the odds of being infected If I wasn't on PEP.

5. I'm on day 12 and I haven't had any symptoms for other STIs other than the cold sore, I applied my cream acyclovir and it healed in just 2 days.



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Edward W. Hook M.D.
37 months ago
Welcome to the Forum. Thanks as well for your confidence in our service.  I'm sorry to hear of your exposure but congratulate you on your response- you are doing everything right.  I'll go straight to your questions:

1.What are my chances of contracting HIV since she is positive and not on treatment?
Statistically, your risk of acquiring HIV following an exposure to an untreated, infected partner is 1 infection per 1000 exposures, i.e. chances are 99.9% that you will not be infected.  PEP further decreases your chance of becoming infected by an estimated another 90%.  The odds are in your favor that you will not be infected.

2.Is my PEP treatment after 30 hours going to prevent transmission?
The sooner you initiate PEP, the more effective it is likely to be.  The official recommendations are the earlier PEP is started, the better with little benefit after 72 hours frollowing expsoure. You did well to get started on PEP at 30 hours.

3.I have a wife,  and I have been avoiding sleeping with her, will I put her at risk if I engage in unprotected sex with her?
In your situation, the best course of action is to avoid unprotected intercourse with your regular partner.

4.I'm taking PEP consistently everyday sametime in the morning can you let me know the odds of being infected If I wasn't on PEP.
See my reply to question 1

5. I'm on day 12 and I haven't had any symptoms for other STIs other than the cold sore, I applied my cream acyclovir and it healed in just 2 days.
In may people, cold sores are more likely during periods of stress- you situation certainly qualifies.  

I hope this information is helpful.  EWH
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37 months ago
Thank you Dr
What is the best test I can do to get conclusive results after I finish my PEP course?
Is seroconversion after taking PEP as prescribed a common occurrence?
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Edward W. Hook M.D.
37 months ago
Seroconversion following PEP is uncommon.

PEP treatment failures are relatively uncommon.  Results of HIV testing using a 4th generation, combination HIV antigen/antibody test taken 4-6 weeks after completion of PEP are considered conclusive.  Some individuals choose to test sooner or to test with an HIV RNAS PCR test but the 4th generation test at 4-6 weeks is the gold standard and experience with other tests is limited.  EWH
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37 months ago
Thank you for you for your responses, I was extremely worried. I think I'm overreacting to the situation.