I received oral sex from a young lady.  The next day I felt a paper cut sensation on the side of my penis.  I began to experience urinary symptoms difficulty starting stream incomplete emptying.  Frequency.  I completed a series of std tests PCR for the standard diseases....all neg for chlaymydia, gonorhea syphilllis,. trich, HIV Herpes, Hepatitis.....mycoplasma Gen and hominis...ureaplasma U and Parvum.  As symptoms kept progressing i retested with Pathonistics,...twice to include prostate fluid....another lab similar to pathnostics...and retested PCR everything again..once again all neg....Prostate began burning around 5 weeks....was told recent hernia surgery might have caused Chronic Pelvic Pain Syndrome...do pelvic floor exercises...after months of getting no improvement....retested by swab and was postive for Ureaplasma Parvum and Mycoplamsa Hominis....many say these are pathogenic...I know the esteemed Dr Handsfield disagrees,,,,but i treated anyway....30 days doxycycline and 5 days azith....repeat swab and PCR urine for both ureaplasmas and both mycoplasmas are negative...burning prostate pain and urinary symptoms continue.  Some say inflammation from eradicated parvum/hominis take nsaids....others say ureaplasma and mycoplasma are now in the prostate and cant be eradicated.  I am miserable and completely stumped...a Microgen test showed only ecoli in the NGS low load.  But i understand that test is flawed...Dr Handsfield writes that many NGU infections are never identified.....did i likely get some demon mouth bug that no test can ID?   Or should i suspect inflammatory reaction  to hernia mesh?  appreciate any help you can provide...god bless you for the work you are doing.

Welcome to the forum. Thanks for your question.---
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Thanks so much Doctor......while the urinary symptoms came on two days after the oral exposure....they also came on 6 weeks after laproscopic surgery with double inguinal hernia mesh.  I was catheterized during this surgery....while repeated UTI cultures showed negative for Ecoli...as did numerous Pathonstics prostate fluid tests....My Microgen test showed Ecoli in the Nest Generation Sequencing....is it possible that the catheter could have infected me with a slow growing Ecoli that would have taken 6 weeks to show symptoms?  I spoke to another individual who was catheterized for surgery who got Ecoli symptoms at 6 months?  I can assure you these symptoms are not psychological...as i did not believe i could catch anything from oral sex.....the burning symptoms are very real....though perhaps inflammation from the mesh which i am having removed in several weeks.  Thanks so much for your comments on the Parvum and Hominis  there are Reddit pages that insist these bugs cause symptoms with thousands of members so it gets confusting...Again god bless for you for your quick response...

I see I missed your mention of the positive test for E. coli in your original question. Apologies. Urinary tract infections due to E. coli or similar bacteria is a common complication of genitourinary surgery, catheterization, etc, but this isn't an STI and the topic is beyond the scope of this forum. I can say that some such infections may persist a long time, especially in the prostate gland, and prostate infections can be difficult to eradicate because of poor antibiotic penetration into the prostate. Further, the presence of the organism in "low amounts" is consistent with a localized infection somewhere in the urinary tract, like the prostate. A persistent small focus elsewhere in your urinary tract also is plausible -- things like a bladder diverticulum, a small renal (kidney) abscess, or others. In any case, NGU due to fecal bacterial like E. coli is rarely if ever a consequence of oral sex -- I've never heard of that happening, although it it isn't rare after insertive anal sex.---

thanks....microgen is notorious for being inaccurate....is there a definitive ecoli test that you trust ?  and is it possible ecoli could manifest over 6 weeks after surgery?  thx for the followup

Sorry, I have no direct knowledge or experience with Microgen. But for nucleic acid (DNA, RNA) testing in general, I would trust a positive result, if care has been taken to avoid contamination (i.e. a careful "clean catch" specimen). A positive culture is conclusive, but routine urine culture standards ignore low organism numbers. Your doctor could advise the lab to report any E. coli (and other typical UTI pathogens) regardless of colony count. However, a negative result will not conclusively rule out a small, localized infection focus, e.g. in the prostate. When a prostate infection is a consideration, the usual approach is a "3-glass" urinalysis and culture:  1) Clean catch midstream; then digital prostate massage, with culture (2) of any fluid expressed and/or (3) the first ounce of urine voided after the massage. Quantitative differences in a UTI pathogen, such as E. coli, can help localize the infection site. Various imaging studies (like prostate ultrasound, Xray, CT, MRI) often are indicated as well. All this is where the expertise and experience of an ID specialist and/or urologist comes into play, and is among the reasons you should seek such consultation. ---