I’m a male that met a female at the bar last night. She performed unprotected oral sex on me for less than 5 minutes. It was a one night encounter so I do not know her sexual history.. The day after this encounter I took 500mg of cipro and 100mg doxycycline and plan to continue the doxy for 7 days to be safe. I am married and my spouse would not approve of this encounter. My last STD test was several years ago and I was only positive for HSV1 What is my risk level for any STI/STD, including HSV2? Is there any issue with taking the antibiotics I described to be safe or other preemptive treatment I should try?  Would you recommend testing and if so, should I wait to become symptomatic before doing so? How long do I need to remain asymptomatic before being intimate with my spouse again to protect her from a possible infection? Thank you and I apologize for the multiple questions. 

Welcome back to the forum. You asked a very similar question 5 years ago, also describing an oral sex event. The answer hasn't changed. Oral sex is safe sex -- not completely free of STI risk, but must lower risk than vaginal or anal sex. ---

I know you said that you would not have recommended taking antibiotics but I do have a follow up question. Would a 1.5g dose of Zithromax be effective in treating gonorhea if present ?

The recommended dose of azithromycin for gonorrhea is 2 g.---

Thank you. I did end up taking 2g azithromycin and will take my last 100mg of doxy tomorrow.

Having taken those antibiotics, there is no point in urine testing for gonorrhea and chlamydia. There was little if any risk to start, and doxy and/or azithro would have aborted or eradicated either of them if you had been exposed, with negative test results. There is no way to ever know whether you might have been exposed to or had early infection with either of them but were cured. Same for NGU and syphilis. Don't waste money on it.---
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Thank you Dr. Handsfield. It’s now been 10 days and I have no ulcers/blisters. My anxiety for anything other than HSV2 is gone at this point. I have seen you use different phrases to describe a potential hsv2 oral to genital infection like low risk, virtually zero, and that you have never heard or seen of genital hsv2 aquire through oral. Can you further elaborate on potential risk here and is it safe to say at this point I am in the clear?

I have never seen a case of genital HSV2 acquired by oral sex, and neither has Terri Warren, the forum's herpes expert -- and she has cared for over a thousand patients with genital herpes. Oral HSV2 is rare, therefore not transmitted by oral sex. You definitely are in the clear.---