As you likely know, tacrolimus is a potent immunosuppressant, and it is logical that it might increase the chance of HPV reactivation. In searching the medical literature, I find a two publications, reporting a total of 3 patients, that suggest this may happen from time to time -- one of facial warts in a child and another report of two cases of genital HPV reactivation with development of warts, documented in those two cases as caused by HPV6 and 11. Neither patient had previously diagnosed genital warts. In all three patients, the warts appeared in exactly (and only) in areas to which the ointment had been applied. Both publications were over 15 years ago (2007). Rare case reports don't mean very much -- any single occurrence could be coincidental -- and there are no systematic data, such as published research on the topic. On the other hand, both reports are well written by seemingly competent clinicians, and the association of reactivated HPV with warts in these three patients doesn't seem coincidental. So my reply must be that this it might be a problem, but I cannot cannot judge the actual risk, i.e. its likelihood in any particular patient.  

I hope this information helps a little bit. Let me know if anything isn't clear.

HHH, MD