Anyway, I took one or two Truvada pills in the middle of my bender or right after it, I don’t quite remember, then I stopped it. 5 weeks post encounter I am negative for HIV and everything except chlamydia in my rectum, which wasn’t surprising. 

Can I trust my HIV 4th gen results 5 weeks post encounter with the Truvada? I currently have a very sore throat and was relieved with the results but now I’m not sure if I can trust them. 

As you probably understand, there are no data on which to base an answer to this question. However, it is unlikely that only 1-2 doses of Truvada would alter the time to reliable negative testing for HIV. Negative HIV AgAb (4th generation) blood tests are 98-99% conclusive by 5 weeks, 100% conclusive by 45 days (which we generally round off, on this forum, to 6 weeks), so you'll want to have one more test at least at that time. If you'd like a bit of extra certainty, perhaps one more test at 8 weeks, which I am sure would be conclusive.

It is not possible to have HIV symptoms and not have detectable antibody. Although your negative test result at 5 weeks may not quite rule out HIV, it does prove your symptoms are not due to a new HIV infection. And of course we're at the peak of cold season; and Covid of course is a possibility as well. But not HIV.

I hope these comments are helpful. Let me know if anything isn't clear.

HHH, MD