[Question #9864] Follow up
28 months ago
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Hi Drs.
Since this might fall under the umbrella of repeated anxiety driven questions, this will be my last. I am aware that I do not have chlamydia, but I would like some information as to why chlamydia rarely infects the throat. Is it due to the type of cells that line the oropharynx? In your clinic have you ever had a patient whose only exposure was oral sex? I have read some sites say that pregnant women are given amoxicillin for treatment, hypothetically speaking… if exposed would starting augmentation at 875/125 prevent infection if started with in a day or two of exposure? I have seen some replies where DR HHH has said augmentin would have no effect and some comments where Dr EWH has said some effect.
28 months ago
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I’m sorry I thought of another question, trying to get it all in one comment for fewer responses. Dr.HHH stated oral chlamydia rapidly clears, is there a timeline where 100% are cleared?
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H. Hunter Handsfield, MD
28 months ago
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Welcome back. We briefly discussed your OCD during your previous thread. Indeed I would put this question in the anxiety category, and in any case it is unrelated to your exposure since your mouth and throat apparently were not exposed so no possibility you have oral chlamydia.
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The biological reasons for the infrequency of oral chlamydia aren't known, but it certainly might involve differences between various types of cells and their susceptibility to chlamydial infection.
I've never had a patient with chlamydia, either genital or oral, whose only likely exposure was oral sex, either giving or receiving. As it happens, I was the senior author on one of the first studies that showed the rarity of chlamydia in people with urethral infection following receipt of oral sex. In fact, none of the patients with nongonococcal urethritis after oral sex had chlamydia (https://pubmed.ncbi.nlm.nih.gov/9153736/). These results were based on culture, which misses some cases detected by NAAT, but it illustrates the rarity of acquiring chlamydia by such exposures. Some positive throat NAAT for chlamydia are believed to not actually indicate chlamydial infection, but detect the residual of recent oral exposure -- i.e. a partner's chlamydia that didn't actually take hold in the infected person. (Many or most studies were done in especially sexually active persons, like men having sex with multiple male partners, STD clinic attendees, and so on. Many probably had been exposed within the past few hours or days.)
You might have interpreted something I wrote on the forum out of context. I don't think I ever said amoxicillin (either alone or in combination with clavlulanic acid, i.e. Augmentin®) has no effect on chlamydia. Indeed taking it soon afrte exposure would have reduced (but maybe not eliminated) whatever risk there was from your exposure. But you later received azithromycin, so why does it matter? Anyway, for the reasons discussed there is no realistic possibility you acquired chlamydia during the oral sex event on your mind.
For the most part, positive oral NAATs for oral chlamydia revert to negative within two weeks.
Do your best to stop obsessing about this -- including combing through the forum for our advice in other cases. If you feel compelled to do that, you must interpret all our replies in the specific context of the questions asked and not over-generalize to different situations.
Best wishes-- HHH, MD
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28 months ago
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Thank you for the reply. I do much better with facts. You may close the thread
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H. Hunter Handsfield, MD
28 months ago
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Thanks for the thanks. I'm glad to have helped. Best wishes and stay safe.---