[Question #999] HSV 2 possible false positive

51 months ago
Hello,
I am immune comprised for about 3 yrs now. I get  Mono about twice a year which is a herpes based virus. I was not on Immunoglobulin IV therapy at time of Herpes test. I did a random Herpes test before starting a new relationship which I always do before and after relationship and only 4 partners with a condom.The test came back positive for HSV1 and HSV2. I have never had an out break of either of these. My question: Is there a possibility of a cross reactive response w mono (Epstein barr) and HSV's to cause a false positive?  Thanks Sunny
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
51 months ago
No, having a history of mono would not cause a herpes IgG antibody test to be falsely positive.  Do you recall the number associated with your positive HSV 2 result?  There are false positives possible on this test in the low positive range (1.1 to 3.5).  Only about 5.5% of people who do the IgG test fall into this range but it would be good to know if your result is low enough to need confirmation.

Terri
---
51 months ago
Hello Terry, I tested positive for a reactivation of mono  the same week as the herpes test. My number was 9 Hsv2 . 6 months later I re tested and it was down to 4. I struggle w being compromised as i am with no outbreaks. Immune compromised always has more outbreaks. My ex and i were tesed 16 yrs ago both being negative at that time. I haven't been with anyone, i did my usual  after breakup test. This is what I discovered. Naturally I wonder if cross reaction since my risk was extremely low. 
51 months ago
Hello Terry, I did think of a question after I sent my lab results to you. If my follow up question is expired let me know. I receive IVIG immunoglobulin therapy now every month, so i receive everybody antibodies now. My question: Would the Western Blot test at University of Washington still be very accurate test to have done for herpes even though have infusions now? I live in Omaha but read I could overnight w ice packs. Thanks for your time.
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
50 months ago
I'm honestly not clear about any impact that IVIG immunoglobin might have on your testing with western blot but I think none.  However, if you do do the blot, I think it would be best to call the UW lab and ask them that question.  There's' no point in doing a confirmatory test if you'll always be wondering about the accuracy, right?  I can understand, given your previous negative antibody test, how you would be wondering what the heck is going on here. 
Best
Terri
---
50 months ago
Thanks I truly appreciate your time.
Terri Warren, RN, Nurse Practitioner
Terri Warren, RN, Nurse Practitioner
50 months ago
You are most welcome

Terri
---